A global revolution in the use of antimicrobials is needed, according to a government backed report.
Lord Jim O'Neill, who led the Review on Antimicrobial Resistance, said a campaign was needed to stop people treating antibiotics like sweets.
It is the first recommendation in the global plan for preventing medicine "being cast back into the dark ages".
The report has received a mixed response with some concerned that it does not go far enough.
Superbugs, resistant to antimicrobials, are estimated to account for 700,000 deaths each year.
But modelling up to the year 2050, by Rand Europe and auditors KPMG, suggests 10 million people could die each year - equivalent to one every three seconds.